讲座主题：New Strategies for Skeletal Editing of Non-Aromatic Heterocycles

主讲人简介：

XU MINYU教授，2012年6月在新加坡南洋理工大学获理学学士学位，2017年12月在波士顿学院获博士学位，2017年1月至2017年6月在波士顿学院从事博士后研究，2017年6月加入新加坡国立大学。主要研究方向为环境友好催化、糖化学和材料化学。获Asian Core Program Lectureship Award（2次）、Thieme Chemistry Journal Award等奖项。

主讲内容简介：

The polarity reversal of classical functional groups offers a powerful yet underexplored strategy in synthesis, enabling disconnections that bypass the constraints of traditional two-electron pathways. A striking example lies in heteroatom-stabilized allylic anions, which act as ambident nucleophiles and can serve as acyl anions or homoenolate equivalents.Despite their conceptual appeal, practical application has been hindered by longstanding issues with regioselectivity and the near-total absence of stereocontrol. This presentation will highlight our recent development of enantioselective reactions that construct allylic and homoallylic acyclic tertiary and quaternary stereogenic centers in complex bioactive molecules. Our approach merges a highly conserved enantioselective transformation with a stereospecific rearrangement, enabling the precise relay of stereochemistry to a remote site. These advances unlock streamlined access to elusive acyclic remote stereocenters, revealing new frontiers for polarity-reversed nucleophiles in asymmetric synthesis.

时间：2026年6月5日（星期五）9:30

地点： 行政保障中心A102

主办单位：科技处（科技成果转化中心）

承办单位：药学院、四川抗菌素工业研究所