讲座主题：Expanding Axial Chirality through N-Heterocyclic Carbene Catalysis

主讲人简介：

Akkattu T. Biju教授，印度科学院院士，Indian Institute of Science教授，Synthesis副编辑。在印度喀拉拉邦Sacred Heart College Thevara (affiliated to MG University)获理学硕士学位；在印度特里凡得琅CSIR-NIIST (Formerly RRL)获博士学位，师从Vijay Nair 博士；在台湾大学跟随Tien-Yau Luh 教授做博士后，以及在德国Universität Münster跟随Frank Glorius 教授做亚历山大·冯·洪堡学者。2011年6月，在印度浦那CSIR-National Chemical Laboratory开始独立研究生涯。2017年6月起，转到Department of Organic Chemistry, Indian Institute of Science，任教授。Biju教授的研究重点是开发使用 N-杂环卡宾（NHC）有机催化，以及芳炔、供体–受体环丙烷和双环丁烷的张力释放驱动反应的策略。

主讲内容简介：

Organocatalysis using N-heterocyclic carbene (NHCs) has been widely utilized for the polarity reversal of aldehydes (umpolung).1 Although NHC catalysis is well demonstrated for the enantioselective synthesis of target molecules, related application to the synthesis of axially chiral molecules is limited (especially the heteroatom-containing axis). We have recently reported the NHC-catalyzed atroposelective synthesis of C-N axially chiral N-aryl succinimides,2 phthalimides/maleimides,3 pyridinones,4 N-N axially chiral 3-amino quinazolinones,5 indoles and pyrroles as well as C-O axially chiral diarylethers.6 In addition, precise control over S(VI) and P(V)-stereogenic centers have recently be achieved by the enantioselective synthesis of N-acyl cyclic sulfonimidamides and phosphacycles.7 The details of these works will be discussed.

时间：2026年10月17日（星期六）上午9:30

地点：行政保障中心A102

主办单位：科技处（科技成果转化中心）

承办单位：药学院、四川抗菌素工业研究所